Effects of OspA Vaccination on Lyme Disease Serologic Testing
نویسندگان
چکیده
منابع مشابه
Effects of OspA vaccination on Lyme disease serologic testing.
This study presents the effects of OspA vaccination on two-step testing for Borrelia burgdorferi antibodies. Although vaccinees developed enzyme-linked immunosorbent assay reactivity, immunoblots did not fulfill Centers for Disease Control and Prevention criteria for positivity. Furthermore, OspA reactivity did not interfere with interpretation of immunoblots with sera from patients who develop...
متن کاملSerologic Testing in Lyme Disease
Topic Overview: How should a clinician employ serologic tests in a Lyme disease evaluation? Before ordering an ELISA or Western blot the clinician should develop a clinical impression of the patient, taking into account the exposure history, symptoms and exam findings. If Lyme disease is judged to be a diagnostic possibility then testing is reasonable. Neither ELISA nor Western blot testing is ...
متن کاملAppropriateness of Lyme disease serologic testing.
BACKGROUND Although rapid diagnosis of Lyme disease is essential for effective treatment, there is concern about inappropriate testing. We conducted a prospective, cross-sectional survey of clinicians to assess the use and appropriateness of Lyme disease serologic tests (LDSTs). METHODS LDSTs performed at 2 large Wisconsin reference laboratories were systematically sampled for 12 consecutive ...
متن کاملRecombinant assay for serodiagnosis of Lyme disease regardless of OspA vaccination status.
All current seroassays using cultured Borrelia burgdorferi as their antigen source have been rendered obsolete by the recombinant OspA Lyme disease vaccine. OspA is the major outer surface protein expressed in cultured B. burgdorferi, and any seroassay that uses whole organisms as its antigen source cannot differentiate between subjects who received the vaccine and those who were naturally infe...
متن کاملEarly and specific antibody response to OspA in Lyme Disease.
Borrelia burgdorferi (Bb), the cause of Lyme disease, has appeared not to evoke a detectable specific antibody response in humans until long after infection. This delayed response has been a biologic puzzle and has hampered early diagnosis. Antibody to the abundant organism-specific outer surface proteins, such as the 31-kD OspA, has rarely been detected less than 6 mo after infection. Antibody...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 1999
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.37.11.3718-3721.1999